几种姜黄素类1，4-戊二烯-3-酮衍生物的合成及结构表征

摘要

T hree kinds of curcumin-type 1 ,5-diaryl-1 ,4-pentadien-3-one derivatives , 1 ,5-bis (3′-methyl-2′-thienyl )-1 ,4-pentadiene-3-ketone (Ⅰ ) , 1 ,5-diphenyl-1 ,4-pentadiene-3-ketone (Ⅱ) and 1 ,5-furyl-1 ,4-pentadiene-3-ketone (Ⅲ ) were designed and synthesized with aromatic aldehyde and ketone as the raw materials . T he composition and structure of as-synthesized products were characterized by elemental analysis ,infrared spectrometry and nuclear magnetic resonance (1 H NMR ,13C NMR) spectroscopy .Moreover ,the reaction conditions and reaction mechanisms were preliminarily discussed .Results show that target products can be obtained in relatively high yield at 30-50 ℃ in the presence of ethanol as the solvent and 8% NaOH solu-tion as the catalyst .%以芳香醛和酮为原料，合成了3类姜黄素类1，5-二芳基-1，4-戊二烯-3-酮衍生物：1，5-二噻吩基-1，4-戊二烯-3-酮（Ⅰ）、1，5-二苯基-1，4-戊二烯-3-酮类（Ⅱ）和1，5-二呋喃基-1，4-戊二烯-3-酮（Ⅲ）；利用元素分析、红外光谱、核磁共振谱（1 H NMR及13C NMR）分析了产物的组成和结构，初步探讨了其反应条件和反应机理。结果表明，以无水乙醇为溶剂、8％的NaO H溶液为催化剂，反应温度为30～50℃时，反应产率较高。