邻氯甲苯直接硝化法合成6-氯-3-氨基甲苯-4-磺酸

摘要

邻氯甲苯混酸硝化合成6-氯-3-氨基甲苯-4-磺酸(CLT酸)因其产率低及选择性差而未能实现工业生产,本文对该工艺进行了改进,采用酸性β沸石和乙酰硝酸酯作为催化剂和硝化剂,提高了硝化选择性和收率,分别为72％和97％；并改进了还原、异构体分离和磺化操作；CLT酸总收率提高到61％.%Because of low yield and poor selectivity,direct nitration of o-chlorotoluene with mixed acid failed to achieve application in industrial synthesis of CLT acid. The use of zeolite-beta in its proton form as catalyist and acetyl nitrate as nitrating agent,increased the yield (97% ) and selectivity of nitration (72% ). And reduction,isomer separation and sulfonation process were improved. Overall yield of CLT acid was 61 %.