以无水哌嗪为原料,合成了9个1,4-位分别带有磷酰化氨基酸和缩氨基硫脲取代基团的哌嗪衍生物,通过1 H NMR、13C NMR、31 P NMR、IR、MS对其结构进行表征.并通过ESI-MS研究目标化合物与细胞色素的弱相互作用,初步评价了他们的生物活性.%nine target molecules including thiosemicarbazone and /V-phosphoryl amino acid groups were synthesized respectively with the raw material of anhydrous piperazine. The structures of nine compounds were confirmed by 1H NMR、13C NMR、31P NMR、IR and MS. And weak interactions between target molecules and cytochrome were studied,their biological activity was discussed.
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