氨基功能化介孔二氧化硅对布洛芬的吸附和缓释性能研究

摘要

采用后合法对介孔二氧化硅SBA-15进行氨基改性,并以改性后材料NH2-SBA-15为载体,以疏水性药物布洛芬( IBU)为模型药物分子,通过浸渍法把IBU填充到载体的孔道内。利用XRD、低温N2吸附-脱附和FT-IR等测试手段,研究了载体的结构及载体与药物间的相互作用。结果表明,IBU通过扩散和化学吸附作用填充到了载体的孔道内,并且载体表面与IBU间存在较强的化学作用。体外模拟释放实验结果显示,与未改性的SBA-15相比,改性后样品NH2-SBA-15对IBU的释放较慢,体现了明显的药物缓释性能。%Amino-functionalized NH2-SBA-15 mesoporous materials were prepared by a post-synthesis method using 3-aminopropyl-triethoxysilane( APTES) as coupling agent. The model drug ibuprofen was introduced into the channels of NH2-SBA-15 via an im-pregnation process. Using X-ray diffraction,N2 adsorption/desorption and Fourier-transform infrared spectra investigated the structure of the materials and the interaction between IBU and carriers. The results revealed that IBU occupied the internal pores of the NH2-SBA-15 via a diffusion and chemical adsorption processes. Moreover,there existed strong interaction between carboxyl groups in IBU and amine groups on the surface of carriers. In vitro drug release experiments results showed that the release rate of IBU from the sample NH2-SBA-15 decreased remarkably compared with pure SBA-15.