以1-脱氧野尻霉素(DNJ)为原料,通过新设计路线合成中间体N-苄氧羰基-2,3,4,6-四-O-苄基-1-脱氧野尻霉素,并在此中间体的基础上通过氧化、氘代硼氢化钠还原,脱保护得到C-6氘代DNJ衍生物,最后考察了目标化合物对α-糖苷酶抑制活性.%The key intermediate2,3,6-tri-O-benzyl-N-benzyloxycarbonyl-l,5-dideoxy-1,5-imino-D-glucitol was synthesized from natural product DNJ by new synthetic route. Then based on the intermediate,the final product C-6 deutero DNJ was synthesized through oxidation,reducing by sodium borodeuteride and eprotection. Finally,theα-glucosidase inhibitory activity of the target com-pound was investigated.
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