4-氯咪唑并三嗪类化合物的合成研究

摘要

以5-咪唑羧酸乙酯为原料,通过氨基化、酰化、氨解环合和氯代反应,合成了三个4-氯咪唑并三嗪类化合物,总收率分别为22.4%,25.1%,20.9%;中间产物及目标产物结构经核磁氢谱1HNMR进行了表征.与传统方法相比,该法具有原料便宜,路线简短,操作简单,反应条件温和等优点.%The title compound of 4-chloro imidazotriazines were prepared from ethyl imidazole-5-carboxylate.The total yield were 20.9~25.1%.The structures of intermediates and target products were characterized by 1HNMR.Compared with the traditional method,the method had the advantages of cheap raw materials,short route,simple operation and mild reaction conditions.