基于天然高分子基元的阻隔层对磁性载药聚乳酸微球的控释作用

摘要

利用层层组装技术构建了基于天然高分子壳聚糖和海藻酸钠的阻隔层,并研究了该阻隔层对磁性载药聚乳酸微球的药物释放作用.实验结果表明,阻隔层能够有效抑制模型药物的突释,具有延缓药物释放的效果.具有阻隔层的磁性载药体系具有药物释放平缓和生物相容性高等特点,是理想的磁靶向载药体系.%Polylactic acid(PLA) microsphere is an ideal drug carrier with high tolerance to the human body and the capability of carrying a wide range of drugs. However, the burst release of drug from the drug-loaded microspheres limit its effective application. Constructing a barrier layer at the surface of microspheres is an effective way to control the burst release of drug. A barrier layer consisting of natural polymer chitosan and sodium alginate was constructed by employing the layer-by-layer assembly technology. Furthermore, the effect of the layer on the drug release from magnetic PLA microsphere was investigated. The experimental results demonstrated that the barrier layer could effectively restrain the burst release of model drug, thus delaying the drug release. The magnetic drug delivery system constructed in this study is a promising magnetic targeted drug delivery system which allows the sustained release of drug and has high biocompatibility.