SERS生物传感技术及其应用进展

摘要

Biomolecule-assisted surface-enhanced Raman scattering ( SERS ) sensing is a technique using biological molecules as sensitive components or detected objects, which is one of the most important tools in the studies of biological molecules. SERS biosensing is widely used in environmental monitoring, food-safety, clinical testing, disease diagnosis, and many other areas. This paper summarizes the progresses on the application of SERS technique in the fields of the analysis and diagnosis of cancer. The contents mainly consist of three parts:(1) SERS biosensing technology based the new coupling mechanisms, involving SPR-coupling, waveguide-coupling and LSPR-PSPR coenhancement; ( 2 ) preparation and application of highly sensitive SERS chips;and (3) new SERS technology for investigating cancer cells and bio tissues.%表面增强拉曼散射( SERS)生物传感技术是以生物成分为敏感元件或探测对象，研究生物分子间相互作用的重要工具之一，被广泛应用于环境监测、食品安全、临床检验及疾病诊断等众多领域。本文总结了耦合增强SERS生物传感技术方面的进展及其在分析检测和癌症诊断方面的应用。主要包括基于耦合增强SERS 生物传感技术方法、高灵敏度的SERS传感芯片的制备及其应用和新型SERS技术研究癌细胞及组织。