金属催化和酶催化在很长时间被认为是两个不同的领域，动态动力学拆分反应是金属-酶协同催化的成功应用。如何有效地协同金属催化的消旋化与酶催化的动力学拆分是其中的关键问题。本文对金属-酶协同催化动态动力学拆分醇和胺类化合物进行了综述，重点介绍了动态动力学拆分中常用的金属催化剂，各种金属与酶的协同，并对其前景进行了展望，指出提高酶在反应体系中的稳定性是未来的发展方向。%Enzyme and metal catalysis used to be considered as unconnected just like “two sides of a medal”. Chemoenzymatic dynamic kinetic resolution is an important application of metal complexes in cooperative catalysis with enzymes. The key point is how to cooperate racemization by metal and to conduct kinetic resolution by enzymes effectively. Racemization of a substrate with a metal complexes combined with a stereoselective transformation of the substrate catalyzed by an enzyme by kinetic resolutions dynamic was reviewed. The metal catalysts used in dynamic kinetic resolution and the coordination of various metals and enzymes were mainly introduced. In the final part of the perspective,improving the stability of enzyme in the reaction system is thought to be the future research direction.
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