Stereoselective Metal-Catalyzed C-C Bond Coupling Reactions by Stereoconvergence, Dynamic Kinetic Asymmetric Transformation, or Dynamic Kinetic Resolution

摘要

The development of stereoselective metal-catalyzed cross-coupling reactions over the past 30 years has revolutionized the way in which C-C, C-N, and C-X bonds are formed in an enantiomerically pure form. In particular asymmetric reactions that transform racemic substrates into enantioenriched products in high, ideally quantitative, yields are particularly appealing. Consequently, many deracemization processes have been developed, implying conceptually diverse strategies such as dynamic kinetic asymmetric transformation (DYKAT), dynamic kinetic resolution (DKR), and stereoconvergence. In this review the most recent achievements in dynamic metal-catalyzed cross couplings of racemic substrates are collected and discussed according to the nature of the deracemization step.