柴胡皂苷类药效分子机制研究最新进展

摘要

柴胡皂苷为齐墩果烷型三萜皂苷，是传统中药柴胡的主要化学和生物活性成分，具有解热、镇静、止痛、镇咳等作用。近期，柴胡皂苷药效分子机制的新研究成果不断涌现，所以总结了现代药理药效学关于柴胡皂苷在逆转多药耐药、防治肝病和保护肝脏、抗炎、抗肿瘤方面的分子机制研究最新进展情况，为其在临床的进一步应用提供参考。%The main bioactive chemical ingredients of traditional Chinese medicine Bupleurum are saikos-aponins, oleanane-type triterpenoid saponins, which are applied in the functions of antipyretic, sepative, analgesic, antibechic. The molecular mechanisms of pharmacological activity of saikosaponins have constantly been revealed. This article reviews recent advances in the effects of saikosaponins on reversing multiple drug resistance (MDR), hepatopretection, anti-inflammatory and anti-tumor. It will provide reference for further application of saikos-aponins in clinical practice.