Fractional Flow Reserve-guided Percutaneous Coronary Intervention:Standing the Test of Time

摘要

Percutaneous coronary intervention(PCI)improves symptoms and prognosis in ischemia-inducing,functionally signifi cant,coronary lesions.Use of fractional flow reserve allows physicians to investigate the ischemia-inducing potential of a specifi c lesion and can be used to guide coronary revascularization,especially in multivessel coronary artery disease.Fractional flow reserve-guided PCI has been extensively investigated.Results show that deferral of stenting in non-signifi cant lesions is safe,whereas deferral of stenting in functionally signifi cant lesions worsens outcome.FFR-guided PCI improves outcome in multivessel disease over angiography-guided PCI.Until recently,there was little known about the long-term outcome of FFR-guided revascularization and its validity in acute coronary syndromes.This review aims to address the new evidence regarding long-term appropriateness of FFR-guided PCI,the need for hyperemia to evaluate functional severity,and the use of FFR in acute coronary syndromes.