Role of technical factors on the Sister Chromatid Exchanges frequency in Human and Primates.

摘要

Biomonitoring human exposed to alkylating agents with theSister Chromatid Exchanges assay(SCEs)and especially theHigh Frequency Cells concept(HFCs)is considered as asensitive approach for detecting a personal exposure.Six yearsafter a two-year chronic exposure of primates to EtO,a highlymutagenic agent,an persistently increased SCEs frequency hasrecently been published.In this experiment,the appearance of ahighly mutated subpopulation of cells(the High Frequency