UV-INDUCED BASE CHANGE MUTATION SPECTRA IN A SHUTTLE VECTOR PLASMID PROPAGATED IN CELLS FROM XERODERMA PIGMENTOSUM COMPLEMENTATION GROUPS A,C AND F.

摘要

To assess the contribution to mutagenesis byhuman DNA repair defects,UV-irradiated shuttlevector plasmid,pZ189,was passed throughfibroblasts derived from xeroderma pigmentosum(XP)patients in DNA repair complementation groups A,Cand F.In comparison to results with DNA repairproficient human cells,UV-irradiated pZ189