ABSENCE OF GENOTOXIC EFFECTS OF RU 486 IN BACTERIAL AND MAMMALIAN CELL SYSTEMS

摘要

RU 486,a potent progesterone antagonist,was testedfor its mutagenic potential at different levels:1)Gene mutations were detected in Salmonellatyphimurium strains recommended by Ames (TA98,TA100,TA1535,TA1537 and TA 1538),over a range of RU 486concentrations from 100 to 5000μg/plate,both withand without rat liver S9 fractions (S9 mix) asmetabolic activation.2) Chromosome damage