OBJECTIVE: To determine genotype-specific distribution of human papillomavirus (HPV) in women and to identify its relationship with cervical carcinoma in Chaoshan population. METHODS:Data from 30000 women who were subjected to cervical HPV DNA testing were retrospectively evaluated in a hospital-based study. A total of 8739 women,who had both HPV typing and pathological examination,were investigated. RESULTS:Overall,30.00%(9000/30000) of women were HPV positive,the frequency of HPV infection was 58.29% (5094/8739) in women with cervical cytological abnormalities,and the infection rate for patients with chronic cervicitis was 40.00% (1088/2720),patients with CIN I was 53.59%(1396/2605),patients with CIN was Ⅱ/Ⅲ 71.61% (1647/2300) and patients with cervical carcinoma was 86.45%(963/1114). HPV 16 (14.02%) was the most common type for all cervical cytological abnormalities,followed by 18 type 6.28%(549),33 type 5.23%(457),58 type 4.46%(390) and 52 type 3.71%(324),while the more common HPV 16 type in cervical carcinoma with the highest infection (49.92%) was in women aged over 60. CONCLUSION:Our data indicate a relatively high prevalence of HPV 16,52,33,58 and 18 in women,their positive association with cervical cytological abnormalities. Specifically,the HPV 16 was the most common subtype among senior women with cervical carcinoma.%目的:检测粤东地区妇女人乳头瘤病毒(HPV)感染情况及亚型分布,探讨其与宫颈癌的关系.方法:选取2015年10月—2016年9月粤东地区7家三级医院30000例行宫颈筛查的妇女作为研究对象.收集所有对象宫颈脱落细胞,采用HybriMax方法对HPV感染情况进行检测.对8739例宫颈病变患者进行宫颈组织活检与HPV分型.比较分析不同病变类型以及年龄段HPV感染率与亚型分布.结果:脱落细胞检查个体中,HPV阳性者9000例,感染率为30.00%.在8739例行宫颈活检的宫颈病变患者中,HPV感染率为58.29%(5094/8739),慢性宫颈炎中HPV感染率为40.00%(1088/2720),CINⅠ中为53.59%(1396/2605),CINⅡ/Ⅲ中为71.61%(1647/2300),宫颈癌中为86.45%(963/1114).在各种宫颈病变中,HPV 16、18、33、58、52是最常见的高危亚型,感染率依次是14.02%、6.28%、5.23%、4.46%、3.71%.在宫颈癌患者中,最常见的亚型是HPV 16;≥60岁的人群中HPV感染率最高,达到49.92%.结论:粤东地区HPV感染最常见的亚型为16、18、33、58、52型,宫颈病变程度越重,HPV的感染率越高.在宫颈癌患者中,HPV 16是最为常见的亚型,中老年患者的HPV感染率高于年轻人,单一感染可能更易导致宫颈癌的发生.
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