人异质性胞核核糖核蛋白A1在消化系统肿瘤中的研究进展

摘要

Heterogeneous-nuclear ribonucleoproteins A1 (hnRNP A1) is one of the important members of hnRNPs family. The function of hnRNP A1 is closely related to RNA transcription, mRNA translation, splicing of splicing sites, splicing site selection, pre-RNA maturation and degradation, cell proliferation and transformation. Overexpression of hnRNP A1 in various types of digestive system tumors is associated with poor prognosis and may serve as an early biomarker for cancer. This article reviews the recent advances in the development of hnRNP A1 and characterizes their roles in cellular and gene expression and in the development of human tumors, highlighting that hnRNP A1 is likely to be an important indicator for tumor prognosis and a potential drug target for the treatment.%人异质性胞核核糖核蛋白A1(hnRNP A1)为hnRNP家族重要成员之一,hnRNP A1的功能与RNA转录、mRNA翻译、外显子的剪接、剪接位点的选择、pre-RNA的成熟与降解、细胞的增生及转化等密切相关,hnRNP A1在各种类型消化系统肿瘤中过表达与患者极差预后相关并可作为早期肿瘤生物标志物.文章综述了hnRNP A1的最新研究进展,描述了其细胞和基因表达及在人类肿瘤发生、发展中的作用.hnRNP A1很可能成为肿瘤预后的一个重要辅助判断指标和治疗的潜在靶点.