肝癌转基因小鼠模型的应用研究进展

摘要

Hepatocellular carcinoma(HCC)is one of the most malignant tumors worldwide. Due to the rapid progress of HCC and the high rate of recurrence and metastasis, the early diagnosis and efficient treatment have been the challenging issues in clinic, and the etiopathogenesis of HCC urgently needs further being clarified. Transgenic mouse models established by genetic engineering provide important research platforms for the etiopathogenesis and drug screening of liver cancer. Combing the classic researches and recent advances, the construction and characteristics of commonly used HCC transgenic mouse models, especially the applications of these transgenic models in HCC basic researches are classified, moreover the developmental prospects of this field are also included.%肝细胞癌是全球范围内的恶性肿瘤，由于其进展迅速、易于复发转移，早期诊断和有效治疗一直是临床难题，对于肝癌的发病机制也亟待进一步阐明。利用基因工程手段构建的肝癌转基因小鼠模型，为肝癌发病机制研究和药物筛选提供了宝贵的研究材料。结合经典研究与近年进展，对常用肝癌转基因小鼠模型的构建方法、模型特点、特别是应用研究状况进行了分类介绍，并展望了未来发展的方向。