抗菌肽高效表达及生产优化研究进展

摘要

Antimicrobial peptides(AMPs),a class of polypeptides induced by external conditions,are encoded by specific genes. In the era of facing the issue of “drug resistance” caused by antibiotics,AMPs own huge potential of benefits to mankind and replacing the antibiotics due to their characteristics of broad-spectrum antibacterial activity,scarce generation of drug-resistance,and antitumor virus,etc. However,the antibacterial activity and instability of natural AMPs should be enhanced,their toxicity should be reduced,and the large-scale production may be achieved by improving the industrial process. Therefore,the recent researches on the molecular modification and design, production and application of AMPS are summarized in detailed here.%抗菌肽是基因编码、经外界诱导产生的一类多肽。在抗生素引发“耐药性”难题的时代，抗菌肽以广谱杀菌、不易产生耐药性、抗肿瘤、抗病毒等特点而拥有超越抗生素、造福人类的巨大潜能。然而，天然抗菌肽还需进行增强抗菌性和稳定性、降低细胞毒性等改造，并通过工业化改良实现大规模生产。因此现从抗菌肽改造设计、生产应用等最新研究做较为详细的综述。