晚期糖基化终产物受体基因多态性与肥胖的关联研究

摘要

Objective To evaluate the association between three single nucleotide polymorphisms (SNPs) of receptor for advanced glycation end-products (RAGE) gene and obesity in Han Chinese population.Methods Totally 2,731 adult subjects aged 18-62 were recruited from a rural population of 14,469 subjects in Jiangsu province by an epidemiological stratification sampling approach.Linkage disequilibrium (LD) analysis was applied and three tagging SNPs (tagSNPs) of RAGE gene,rs1800624,rs204993,rs184003 were selected for genotyping and analyzing for the association with obesity.Results SNP rs1800624 had significant association with obesity and OR (95％ CI) were 0.807 (0.669-0.974) and 0.762 (0.617-0.939)in additive model and dominant models after the adjustment for confounding factors such as age,sex,physical activity index and income.Further stratification analysis by sex indicated that individuals carrying T allele (AT+TT) of SNP rs1800624 had higher susceptibility to obesity than CC genotype in male.No significant difference of BMI was found between genotype variations of rs1800624,rs204993 and rs184003.Conclusions Our result suggests that SNP rs1800624 of RAGE gene is associated with increased risk of obesity in Han Chinese men,and further replication study would be warranted.%目的 分析晚期糖基化终产物受体(RAGE)的遗传变异与中国汉族人群肥胖的关系.方法 研究对象来自江苏省某乡镇农村地区,从18～ 62岁目标人群14 469人中抽取2 731人进行流行病学调查人群资料；选择采用连锁不平衡分析的方法,选取RAGE基因及其上游的3个tagSNPsrs 1800624、rs204993和rs184003进行关联分析.结果 rs1800624位点与肥胖的关联有统计学意义,校正年龄、性别、体力活动和收入等混杂因素后,相加模型和显性模型的比值比(OR值)及其95％可信区间(95％ CI)分别为0.807 (0.669～0.974)、0.762(0.617～0.939).进一步按性别进行分层分析,结果显示,男性人群中,携带rs1800624突变T等位基因型(AT+ TT)者肥胖患病风险增加.不同基因型之间BMI水平比较也未发现上述3个SNPs变异与BMI数量性状存在关联.结论 RAGE基因rs1800624与男性人群肥胖风险增加显著关联.