O,O’二乙基-α-(取代苯胺基)-(取代苯基甲基)膦酸酯的绿色合成

摘要

以芳香醛、芳香胺与亚磷酸二乙酯为原料,无溶剂和催化剂存在下,一锅法合成了6种O,O’二乙基-α-(取代苯胺基)-(取代苯基甲基)膦酸酯.以苯甲醛、苯胺与亚磷酸二乙酯的一锅法反应为模板反应,筛选出适宜的反应条件为:n(苯甲醛)∶n(苯胺)∶n(亚磷酸二乙酯)=1∶1∶1.2,100℃下反应2h,收率达57.7％.采用该合成方法在适宜反应条件下合成其它5种O,O’二乙基-α-(取代苯胺基)-(取代苯基甲基)膦酸酯,收率为51.1％～76.0％.%Six kinds of O,O'di-ethyl-α-(substituted phenylamino)-(substituted phenylmethyl) phospho-nate were synthesized by one-pot condensation reactions of aromatic aldehydes, aromatic amines and O,O' -diethylphosphite. The optimum conditions obtained about one-pot condensation reactions of benzal-dehyde,phenylamine and O,O' -diethylphosphite were as follows:reaction temperature 100 ℃, ,n(benzal-dehyde) :n(phenylamine) : n(O,O'-diethylphosphite) =1:1:1. 2,reaction time 2 h,the yield of the product reached 57.7%. The yields of the others were from 51.1% to 76.0%.