Gadolinium-based nanoparticles(GdNPs)have been used as theranostic sensitizers in clinical radiotherapy study[1],but the biomechanisms underlying the radiosensitizing effect of GdNPs are still undisclosed.In this study,ultra-small gadolinium oxide nanocrystals(GON)was employed to investigate their radiosensitizing effect and biological mechanisms in non-small cell lung cancer(NSCLC)cells under X-ray irradiation.Using a polyol method,GON was synthesized[2].In the previous study,GON caused hydroxyl radical production and oxidative stress in a dose-and concentration-dependent manner in NSCLC cells after X-ray irradiation.The radiation enhancements of GON reached 19.3%26.3%for the NSCLC cells under investigation at 10%survival level compared with irradiation alone.
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