Aim To observe the effect of Amiodarone combined with Irbesartan treating paroxysmal atrial fibrillation. Method From rnMay 2008 to May 2010,83 paroxysmal atrial fibrillation patients were enrolled and randonly divided into treatment group and control rngroup. The treatmrent group was treated with Amiodarone and Irbesartan, and the control group only with Amiodarone. All the patients rnhad been observed for 12 months. Results The sinus rhythm maintenance rate in treatment group was higher than that in control group rnand the atrial diameter decreased remarkably in treatment group than in control group (P ＜ 0.05). Conclusion Irbesartan can inhibit ernlectronic and anatomical remodeling of atrial, reduce the recurrence rate of atrial fibrillation, prevent persistence of atrial fibrillation and rnmaintain the sinus rhythm rate more effectively than Amiodarone only,and it can also inhibit the increase of the left atrial diameter.%目的 观察胺碘酮联合厄贝沙坦治疗阵发性房颤的疗效.方法 选择2008年5月～2010年5月期间该院83例阵发性房颤患者,随机分为治疗组(胺碘酮+厄贝沙坦)和对照组(单用胺碘酮),疗程均为一年.结果 治疗组窦性心率维持率明显高于对照组(P<0.05),左房内径亦有显著性缩小(P<0.05).结论 厄贝沙坦具有抑制心房电重构和解剖重构,降低房颤复发率及阻止房颤持续的作用,胺碘酮联合厄贝沙坦治疗阵发性心房颤动维持窦性心率的疗效优于单用胺碘酮,且能抑制左房扩大.
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