糖尿病肾病患者炎症相关因子水平及临床意义

摘要

Aim To explore the relation between serum inflammatory factors and diabetes nephropathy(DN). Methods To select 150 patients with DN from 2008 to 2009 were selected as subjects. 30 healthy persons were selected as control group. The levels of sIL-2R,CRP,TGF-β1 and IL-6 were detected for all subjects. Results The levels of sIL-2R,CRP,TGF -β1 and IL -6 were all higher among control group than those of patients with DN. The levels of sIL-2R,CRP,TGF-β1 and IL-6 tended to increase as patient' s condition became severer. Conclusion The levels of sIL-2R,CRP,TGF-β1 and IL-6 have a close correlation with the development of DN. The four indexes play important roles in judgment of patient' s condition.%目的 探讨炎症相关因子与糖尿病肾病的关系.方法 选取2008年1月～2010年1月来本院就诊的糖尿病肾病患者共150例作为研究对象,选择同期来本院进行健康体检的30名健康人群作为对照组,检测各组人群sIL-2R、CRP、TGF-β1和IL-6水平,并进行组间比较.结果 健康对照组四种指标水平均低于糖尿病肾病患者,5期糖尿病肾病患者四种指标水平最高,随着患者病情加重,sIL-2R、CRP、TGF-β1和IL-6水平均呈现逐渐增高的趋势(P<0.01).结论 sIL-2R、CRP、TGF-β1和IL-6与糖尿病肾病的发生发展密切相关,是进行病情判断的重要参考指标.