目的 研究COX-2和HER-2在食管鳞癌(ESCC)组织中的表达及与临床病理特征之间关系.方法 采用免疫组织化学方法检测519 例食管鳞癌组织中COX-2 和HER-2的表达水平,分析两者与临床病理特征之间的关系以及两者之间的相关性.结果 COX-2 阳性表达率为 411/519(79.2%),COX-2 的表达与食管鳞癌分期﹑分化程度﹑肿块直径大小,淋巴结转移均无相关性(P>0.05);HER-2阳性表达率为 120/519(23.1%),与食管鳞癌分化程度、淋巴结转移数目呈正相关(P<0.05);而与食管癌分期﹑肿块直径大小无相关性(P>0.05).HER-2的表达与COX-2的表达之间正相关(r=0.151,P=0.01).结论 HER-2蛋白与COX-2蛋白在食管鳞状细胞癌中均有不同程度的表达,COX-2可能是食管鳞状细胞癌发生的早期事件;HER-2蛋白过表达可能是食管癌预后不良的一个指标;COX-2在食管鳞状细胞癌中高水平表达且与HER-2密切相关,提示食管鳞状细胞癌中COX-2和 HER-2存在相互作用机制并共同促进肿瘤的发生及发展.%Aim To investigate the expression and correlation of cyclooxygenase-2 and HER-2 oncogene in esophageal squamous cell carcinoma. Methods cyclooxygenase-2 protein and HER-2 oncogene expression in 519 cases of esophageal squamous cell carcinoma were detected by immunochemical staining and the relationship between COX-2 and HER-2 was analyzed together with the clinicopathologic characteristics. Results 411 cases of 519( 79. 2％)esophageal squamous cell carcinoma samples were positive for cyclooxygenase-2. Overexpression of cyclooxygenase-2 was not associated with TNM stage, histological grade ,lymph node metastasis and the size of tumor( P ＜ 0. 05 ). 120 cases of 519( 23. 1％ )esophageal squamous cell carcinoma specimens were positive for HER-2,which correlated with the factors of histologic grade and lymph node metastasis( P ＜0. 05 ).while not related with TNM stage, the size of tumor. The expression of HER-2 was closely correlated with the expression of COX-2( P ＜ 0. 05 ). Conclusion Both COX-2 and HER-2 overexpress in ESCC. COX-2 seems to be an early event in the development of ESCC. HER-2 may play independent prognosis target rule. The expression of COX-2 is significantly related to the expression of HER-2 , which indicates that HER-2 and COX-2 can regulate each other and induce the tumorgenesis and development together.
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