Objective To study the sensitivity and specificity of 3 types of syphilis clinic detection methods ,the diagnosis method with higher sensitivity and specificity can be chosen . Methods TPHA, TPPA and ELISA were used for assay of 75 cases of syphilis patients and 55 cases of non-syphilis patients. Results For the three assay methods of TPHA, TPPA and ELISA, clinic sensitivities were 91.2% ,97.8% and 98.7% respectively, and specificities were 96. 3%, 98. 5% ,and 98.2% respectively. TPPA had relatively good sensitivity and specificity. As compared with other three methods , ELISA also had good sensitivity and specificity , which had no statistic significance if compared with TPPA (P >0. 05 ). Clinic sensitivity of TPHA was slightly poor , which had statistic significance if compared with TPPA(P<0.05) ;its specificity was relatively good ,which had no statistic significance if compared with TPPA (P>0.05). Conclusion Both TPPA and ELISA are relatively good clinic syphilis assay methods .%目的 对比研究3种不同的梅毒临床检测方法的敏感性和特异性,从而筛选敏感性和特异性较高的诊断方法.方法 采用梅毒螺旋体血球凝集试验(TPHA)、梅毒螺旋体明胶颗粒凝集试验(TPPA)和酶联免疫吸附试验(ELISA)检测75例梅毒患者和55例非梅毒患者.结论 3种检测方法TPHA、TPPA、ELISA的临床敏感性分别为:91.2%、97.8%、98.7%,特异性分别为:96.3%、98.5%、98.2%.TPPA的敏感性和特异性均较好,与其他3种方法相比,ELISA检测方法的敏感性和特异性也较好,与TPPA比较均无统计学意义(P>0.05);TPHA临床敏感性稍差,与TPPA比较有统计学意义(P<0.05),其特异性尚好,与TPPA比较无统计学意义(P>0.05).结论 TPPA、ELISA均为临床较好的梅毒诊断检测方法.
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