丹皮酚渗透泵片包衣膜处方工艺考察

摘要

To review the tablet coating formulation process and the nature of self -made Pae osmotic pump membrane. Methods By water absorption investigation , observation of surface morphology before and after release ,the determination of drug release rate and the con -dition for the preparation of the membrance and its performance were examined . Results Coating material could contain 2. 5% EC, 10% DBP ,10% PEG-4000 in anhydrous ethanol coating liquid , which could prepare flexible , compact, uniform membrane, and this experiment succesfully prepared paeonol sustained release tablets of zero order release. Conclusions Self-made Pae osmotic pump membrane has good proton conductivity . This study provides a reference to establish the quality standard and coating film formulation for the paeonol os -motic pumps.%目的 对自制的丹皮酚渗透泵片进行包衣膜处方工艺考察.方法 将含2.5%乙基纤维素(EC)、10%邻苯二甲酸二丁酯(DBP)、10%聚乙二醇-4000(PEG-4000)的无水乙醇包衣液采用喷雾法制备成丹皮酚渗透泵片包衣膜,通过考察吸水量,观察释药前后的表面形态变化并进行包衣后的释放度测定,对包衣膜进行性质考察.结论 丹皮酚渗透泵片包衣膜柔韧、致密、均匀,能保证适当的水分进入,并且释放度测定表明丹皮酚渗透泵片在12 h能实现很好的零级释放.结论 将含2.5%EC、10%DBP、10%PEG-4000的无水乙醇包衣液采用喷雾法制备成的丹皮酚渗透泵片包衣膜性能良好,为丹皮酚渗透泵片包衣膜处方筛选和质量控制提供了一定的实验依据.