参麦注射液对荷 H22小鼠免疫功能的影响

摘要

目的：研究参麦注射液对荷瘤小鼠免疫功能的影响。方法建立H22细胞小鼠移植瘤模型，将荷瘤小鼠随机分为模型组（荷瘤空白组），参麦注射液三个剂量组，另设空白参考组，每日灌胃给药，通过测定对白细胞总数及分类，sIL-2R、IL-2、IL-4含量，脾淋巴细胞增殖及迟发超敏反应能力的影响，探讨参麦注射液的免疫调节作用。结果参麦注射液可提高荷瘤小鼠白细胞总数；降低荷瘤小鼠血清sIL-2R的含量，提高IL-2，IL-4水平，改善小鼠脾淋巴细胞增殖和迟发型超敏反应能力。结论参麦注射液具有增强机体免疫功能的作用。%Objective To study the immunomodulatory effect of shenmai injection on mice with H 22.Methods After subcutaneous implantation of the H22 cells,the tumor-bearing mice were randomized into control group ,three shenmai doses groups and normal con-trol group.Those mice were given the different doses of shenmai .Immunity function of Shenmai was explored by determining its influ-ence on leukocytes and classification ,the serum content of sIL-2R,IL-2,IL-4,the spleen lymphocyte proliferation and delayed hypersen-sitivity thymus index.Results Shenmai injection significantly increased the white blood cells ,IL-2 and IL-4,decreased the content of sIL-2R,promoted spleen lymphocyte proliferation and delayed hypersensitivity .Conclusion Shenmai injection modulates the immunity function on mice with H22.