肝动脉化疗栓塞联合射频消融治疗乏血供大肝癌的疗效分析

摘要

目的：探讨经导管动脉化学栓塞（transcatheter arterial chemoembolization，TACE）联合射频消融（radiofrequency ablation， RFA）治疗晚期乏血供大肝癌的疗效。方法回顾性分析该院2008年10月—2014年7月收治的40例晚期乏血供大肝癌患者的临床资料，随机分为两组：联合组（TACE联合RFA治疗，21例）、对照组（单纯TACE治疗，19例）。比较两组术后血清甲胎蛋白（AFP）、肿瘤完全坏死率、肿瘤缩小率、肿瘤进展率、术后肝功能变化等指标。结果术后6个月联合治疗组肿瘤缩小率、完全坏死率和肿瘤进展率分别为90．47％、71．43％和14．29％，对照组的分别为63．19％、36．84％和47．37％。两组差异具有统计学意义（P均＜0．05）。结论 TACE联合RFA治疗乏血供肝癌较仅行TACE治疗能提供更好的疗效。%Objective To investigate the value of the combined treatment of transcatheter arterial chemoemhnbolization (TACE)and radiofrequency ablation (RFA)for poor blood supply hepatocarcinoma.Methods 40 cases of poor blood supply large hepatocarcinoma (from October 2008 to July 2014 )patients was divided into two groups:Combination therapy group (treated by TACE in combination with RFA,n=21)and Control group (treated by TACE alone,n=19).postoperative AFP,complete tumor necrosis rate,tumor shrink rate,tumor progression rate and postoperative liver function were detected in the two groups.Results Complete tumor necrosis rate,tumor shrink rate,tumor progression rate rates in 6 months after Interventional surgery of combination therapy group were 90.47%,71.4 % and 14.29%,respectively.While in the control group,complete tumor necrosis rate,tumor shrink rate,tumor pro-gression rate rates were 63.19%,36.84% and 47.37%.There were significant difference of these data between combination therapy group and control group (P<0.05).Conclusion Combination therapy of multipolar RFA and TACE maybe more efficiently to treat poor blood supply hepatocarcinoma than use TACE alone.