脂肪细胞因子在类风湿关节炎潜在生物标志物中的作用

摘要

类风湿关节炎（ rheumatoid arthritis，RA）是一种累及多关节的慢性系统性炎性自身免疫性疾病。近年来，研究一直专注于预测疾病发病、疾病进展、关节损伤和治疗反应的生物标记物。白色脂肪组织作为一种多效性器官，不仅具有内分泌功能，而且参与多种病理生理过程，包括免疫和炎性反应。白色脂肪组织分泌的脂肪细胞因子，参与RA的发病。该文对可能作为疾病活动和治疗反应的潜在生物标记物的脂肪细胞因子的研究进展进行综述。%Rheumatoid arthritis ( RA) is a chronic multisystem systemic inflammatory utoimmune disease characterized by polyarticular injury.Recently,research has been focusing on the possible identification of predictor markers of disease onset and/or progression,of joint damage,and of therapeutic response.Recent findings have uncovered the role of white adipose tissue as a pleiotropic organ not on-ly specialized in endocrine functions but also able to control multiple physiopathological processes,including autoimmune and inflamma-tion.Adipokines are secreted by white adipose tissue which involved in the pathogenesis of RA.This review will focus on the recent advances on the adipokines as potential biomarkers of disease activity and therapeutic response.