自拟天麻川穹汤联合非洛地平及厄贝沙坦氢氯噻嗪治疗老年难治性高血压的临床效果

摘要

Objective To observe the clinical effect of combining Chuanqiong Tianma decoction with western medicine in the treatment of senile refractory hypertension.Methods Sixty-eight senile refractory hypertension patients,who saw their doctor in The Fourth Affil-iated Hospital of Anhui Medical University from July 2012 to July 2015,were chosen and randomized into western medicine treatment group and combined medicine treatment group according to different treatments,with 34 cases in each group.Patients in western medi-cine treatment group took Extended Release Felodipine Tablets and Irbesartan and Hydrochlorothiazide while patients in combined med-icine treatment group not only received the same treatment as patients in western medicine group but also drank Chuanqiong Tianma de-coction.Blood pressure of the patients as well as clinical symptoms such as dizziness,headache,palpitation,insomnia were counted and analyzed.Results Among the 34 senile refractory hypertension patients who received western medicine treatment,11 patients had nota-ble curative effect,12 patients had curative effect,and the rate of blood pressure control was 67.64%;among the other 34 patients who received combined medicine treatment,23 patients had notable curative effect,7 patients had curative effect,and the rate of blood pres-sure control was 88.24%.There were significant difference in blood pressure control between the two groups(P <0.05).The effective rate of clinical symptoms such as dizziness,headache,palpitation and insomnia of the patients who received combined medicine treatment was significantly higher than that in western medicine group(P average <0.05).Conclusions Chuanqiong Tianma decoction combined with Extended Release Felodipine Tablets and Irbesartan and Hydrochlorothiazide could effectively control senile refractory hypertension.%目的：观察自拟天麻川穹汤联合西药治疗老年难治性高血压的临床效果。方法选取68例老年难治性高血压患者，按照治疗不同随机单盲法分为西药组和联合治疗组，西药治疗组给予非洛地平缓释片、厄贝沙坦氢氯噻嗪，联合治疗组在西药组治疗基础上，加用天麻川穹汤，每组各34例。统计分析两组患者血压及头晕、头痛、心悸、失眠等临床症状。结果经西药治疗的34例老年难治性高血压组患者，有显著疗效的有11例，有疗效的患者12例，血压控制率为67．64％；经联合治疗的34例患者，有显著疗效的有23例，有疗效的有7例，血压控制率为88．24％，两组血压控制率比较差异有统计学意义（P ＜0．05）。经联合治疗组患者，头晕、头痛、心悸、失眠等临床症状有效率显著高于西药组（均 P ＜0．05）。结论天麻川穹汤联合非洛地平及厄贝沙坦氢氯噻嗪治疗能有效控制老年难治性高血压。