Objective To analyze the clinical features, blood culture and drug sensitivity of neonatal late onset sepsis, pathogens and drug sensitivity to guide clinical therapy. Methods Clinical features of 34 patients of late - onset sepsis, treated in our department from January of 2008 to December of 2010, were analyzed retrospectively. Results Late - onset neonatal sepsis had no characteristic clinical presentation, Gram - positive cocci dominated the first of which accounted for Staphylococcus epidermidis, the low rate of resistance to third generation cephalosporins, some sensitive classes to aminoglycosides and quinolones, and a higher penicillin resistance. Conclusion The clinical manifestations of neonatal late onset sepsis are lack of specificity. In the early stage, third - generation cephalosporin should be chosen, and then adjust based on susceptibility test results to make a rational use of antibiotics.%目的 分析新生儿晚发型败血症临床特点、病原菌及药物敏感情况,指导临床合理用药.方法 对2008年1月至2010年8月34例晚发型败血症临床特点、血培养结果及药物敏感性进行回顾性分析.结果 新生儿晚发型败血症临床无特征性,病原菌以革兰阳性球菌为主,其中表皮葡萄球菌占第1位,对第三代头孢菌素耐药性偏低,对氨基糖苷类及喹诺酮类较敏感,而对青霉素有较高耐药性.结论 新生儿晚发型败血症临床表现缺乏特异性,病原菌以革兰阳性球菌为主,早期宜选用第三代头孢菌素,再根据药敏调整,合理选择抗生素.
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