Objective To compare the effect of Calsurf ( Calf Pulmonary Surfactant for Injection ) and Curosurf( Poractant Alfa Injection ) in treating respiratory distress syndrome of preterm infants. Methods Sixty premature infants diagnosed as NRDS after birth were divided into three groups. The first group including 20 nonates was dripped in Calsurf through trachea, and the second group was dripped Curosurf, and the third group of another 20 neonates with the same condition served as the control group. Results In the two therapeutic groups, the pH, PaO2 and PaCO2 were improved significantly ( P <0. 001 ). However, the difference between Calsurf group and Curosurf group was not statistically significant ( P >0.05 ). Compared to the control group, the total time of breathing machine was shortened of the two therapeutic groups ( P <0. 05 ). Conclusion The Calsurf and Curosurf can rapidly and effectively help the neonates to improve their pulmonary ventilation, whose therapeutic effects were the same.%目的 比较固尔苏与珂立苏在治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效.方法 确诊 NRDS 患儿60例,20例采用珂立苏治疗,20例采用固尔苏治疗,20例为对照组,分别比较珂立苏和固尔苏治疗组患儿用药前后血气指标(pH,PaO2,PaCO2)的变化情况,比较治疗组和对照组上机时间等.结果 珂立苏和固尔苏治疗组患儿用药前后血气指标比较,差异均有统计学意义(P＜0.05).珂立苏组和固尔苏组治疗前后血气指标差异无统计学意义(P＞0.05).治疗组和对照组比较,上机时间明显缩短,差异有统计学意义(P＜0.05).结论 临床治疗 NRDS时,应首选肺表面活性物质治疗,可显著改善血气指标和机械通气参数,国产珂立苏和进口固尔苏具有同样疗效.
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