卒中后抑郁障碍的相关因素的临床研究

摘要

Objective To investigate the incidence and relative factors of post-stroke depression (PSD). Methods 246 patients with stroke were divided into PSD group and non - PSD group,assessed by CCMD -3,17 - item Hamilton Depression Depression Rating Scales( HAMD), SSS and MMSE. They were assessed by a multiple factor analysis with the logistic regression method on the basis of these data. Results Among them, 32.5% were identified as depression,The minor, moderate and major incidenses were 53.75% , 35.00% and 11.25% respectively. In addition, stepwise regression analysis shows that important risk factors involved in PSD contained family harmony, lesion location, neurological deficit and accompanying disease. Conclusion The factors above were the major predictive factors and useful for PSD prevention and treatment.%目的 观察卒中后抑郁障碍(PSD)的发生率及其临床相关因素.方法 选择246例脑卒中患者作为研究对象,分为PSD组和非PSD组,采用CCMD -3、汉密尔顿抑郁量表(HAMD)和神经功能缺损评定(SSS)及MMSE进行诊断和评估,通过两组间相关因素比较,并经Logistic回归统计学方法进行分析.结果 PSD总发生率为32.5％,其中轻度53.75％,中度35.00％,重度11.25％；对PSD影响有显著意义的相关危险因素是家庭关系不和睦、脑卒中部位、神经功能障碍程度及存在合并症者.结论 上述因素是本组PSD患者的主要易患因素,可为PSD的早期预防和临床干预提供参考依据.