固肠促长散对实验性脾虚仔猪实质器官的组织学影响

摘要

[目的]观察固肠促长散对脾虚仔猪腹泻各实质器官的修复情况。[方法]选取12头健康仔猪为试验组，对其颈部肌肉注射利血平注射液0.5 ml，每天1次，连用10 d。之后将试验仔猪平均分为2组。对固肠促长散组的6头仔猪，将6 g药物用20 ml开水冲泡后，灌服，每天1次，连续灌服7d；对脾虚对照组的6头仔猪，每天灌注生理盐水20 ml，连续7 d。于停药后的第2和第8天，各组分别取3头猪，后颈动脉放血处死。分别制作心脏、肝脏、肾脏、肺脏的石蜡切片并染色，观察各实质器官的组织学变化。[结果]用固肠促长散治疗的腹泻脾虚仔猪，各实质器官的组织学结构修复接近正常。[结论]固肠促长散在仔猪腹泻上起到了较好的治疗作用。%[Objective] This study aimed to explore the histological effects of Guchangcuzhang powder on the parenchymatous organs in experiment piglets with spleen weakness. [Method] For the 12 healthy piglets, 0.5 ml of reserpine was in-jected at their jugular muscle once every day for 10 days. Afterwards, the 12 piglets with diarrhea were divided into two groups, namely the Guchangcuzhang powder group and the control group, six in each. In the former group, 6 g of Guchangcuzhang powder was brewed with 20 ml of boiling water and then the piglets were drenched with the medication solution for 7 d once every day; in the latter group, each piglet was drenched with 20 ml of normal saline once every day for 7 d. On two and eight days after the drug discontinuance respectively, three piglets were selected from each of the group and kil ed by bloodletting from the jugular vein. Afterwards, paraffin sections of heart, liver, lungs and kidney was made and then stained respectively, fol owed by observation of the histological changes. [Result] The histological structure of each parenchymatous organ in piglets drenched with Guchangcuzhang powder restored or approached to normal. [Conlusion] Guchangcuzhang powder has a good therapeutic against diarrhea in piglets.