Morphologic Studies on Experimental Epidemic Encephalitis (Summer Encephalitis) in Monkeys (First Report). Anatomic and Histologic Changes, Especially of the Internal Organs, in Monkeys Infected through the Nose.

摘要

The writers conclude that: (1) The morphologic changes observed in experimental monkey encephalitis are almost identical to those seen in human; (2) After intranasal inoculation of large quantities of virus, the virus readily finds its way into the brain along-side the olfactory nerve. Slight alterations develop in the brain from the time of incubation on. The virus also finds its way into the circulation within the first 48 hours and there gives rise to alterations in a certain sequence; and (3) Not only the central nervous system reacts to the encephalitis virus (summer encephalitis), but also the mesenchymal tissue of all the rest of the body, although the reactions of the latter are not as pronounced.