The histological changes of digestive organs in experimental decreases of hepatic venous outflow at the rat

摘要

The hepatic venous outflow may be diminishing in right-sided heart diseases, constrictive pericarditis, obstruction of suprahepatic veins or an inferior vena cave. It was created an experimental model by obstruction of the suprahepatic veins lumen and inferior vena cave, too, at the adult Wistar rats. The animals were sacrificed in the 30 days after operation. At the iterative laparatomy it was found the liver more increased in volume, a little amount of ascites in peritoneal cavity, oedema of the digestive organs walls. Liver and stomach fragments were prelevated and were processed for optic microscopy and electronic microscopy. The morphological study using by usual technics has highlighted vascular stasis in gastric submucosa. In liver it is standed out the pericentrolobular vascular stasis, inflammatory lymphoplasmocytic infiltrate around the end of hepatic vein. In the gastric submucosa have found vascular stasis, and within the chorion mucosa, the high capillary hyperemia. There is a discreet vacuolar feature on epithelium surface of the gastric mucosal in pyloric region. In the other layers, at rats the epithelium multistratum keratinizated of the stomach is without changes, in this region is maintaining the hyperemia in mucosal chorion.