Compared with advanced heart centers, early mortality rate of radical correction of tetralogy of Fallot (TOF) has been within the control of about 1％～2％,but long-term result is still in need of observation. It is reported that the complications of right ventricular dysfunction and atrial and ventricular arrhythmias become more and serious with the increase of follow-up time. Reports concerning about arrhythmia sudden death which mainly deals with the vital pathophysiologic change of pulmonary regurgitation can often be seen. Serious pulmonary regurgitation needs to be solved by pulmonary valve replacement, however , materials and ways are still explorated actively. This paper summarized the research process of long-term mortality rate and reasons of TOF patients, long-term complications, vital pathophysiologic change, material exploration and valve replacement of it.%法洛四联症根治术早期死亡率较先进的心脏中心已控制在1%～2%左右,但远期预后仍待观察.文献报道,随着随访时间延长,右心室功能不全、房室性心律失常等并发症也随之增多加重,常有心律失常性猝死等报道,而其主要与肺动脉瓣反流这一重要病理生理变化有关;重度肺动脉瓣反流还需要采取肺动脉瓣置换术方式来解决,而对预防肺动脉瓣反流的手术方式和材料还在积极探索中.现就近年来法洛四联症患儿的远期死亡率及原因、远期并发症、重要病理生理变化、材料探索及瓣膜置换的研究进展做一综述.
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