目的探讨联合检测癌胚抗原(CEA)、细胞角蛋-19片段(CYFRA21-1)、鳞癌相关抗原(SCC-Ag)对非小细胞肺癌(NSCLC)的临床应用价值及其血浆水平与NSCLC临床分期的关系。方法应用酶联免疫吸附双抗体夹心法对57例NSCLC患者、30例肺良性病变患者血清中CEA、CYFRA21-1、SCC-Ag的水平进行检测。结果NSCLC 患者血清中CEA、CYFRA21-1、SCC-Ag水平均明显高于肺良性病变患者(P <0.01)。Ⅲ~Ⅳ期 NSCLC 血清中 CEA、CYFRA21-1 SCC-Ag含量明显高于I~II期(P<0.05)；多项指标联合检测时，以CEA、CYFRA21-1、SCC-Ag组合获得的敏感性最高(P<0.05)。结论联合检测 CEA、CYFRA21-1、SCC-Ag可起到互补作用，从而明显提高NSCLC的阳性检出率，且肿瘤标志物水平随病情的进展而升高。%Objective This study evaluated the diagnostic value of combined measurement of CEA, CYFRA21-1 and SCC-Ag in non-smal1 cell lung cancer(NSCLC);we evaluated their relationships in different clinical stages of lung cancer by detecting CEA, CYFRA21-1 and SCC-Ag level changes of serum in patients with NSCLC. Methods The level of CEA, CYFRA21-1 and SCC-Ag in serum were detected by ELISA in 57 newly-diagnosed patients with NSCLC and 30 patients with benign lung diseases were served as the control groups. Results The serum lev-els of CEA, CYFRA21-1 and SCC-Ag in patients with NSCLC were significantly higher than those in the contro1 groups (P<0.01). The level of CEA,CYFRA21-1 and SCC-Ag in serum in patients with stage Ⅲ~Ⅳ NSCLC were significantly higher than those with stageI~II(P<0.05). The sensitivity was increased when three mark-ers were used in combination. Conclusion Combined use of CEA, CYFRA21-1, SCC-Ag measurement may play a marked role and evently raise the detection rate of NSCLC compared with the use of any single marker. In addi-tion, the level is found to increase with development of the disease.
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