伊马替尼疗效与晚期胃肠间质瘤临床病理特征分析

摘要

Objective To explore the effect of clinicopathological features on the curative effect of Imatinib in ad-vaced gastrointestinal stromal tumor ( GIST) . Methods Retrospectively analyzed the clinicopathological data of 74 diagonosed patients with advanced GIST by histopathology and immunohistochemistry between September 2007 and July 2012 in The First Affiliated Hospital of Anhui Medical University. The impact factors of the curative effect of Imatinib were evaluated. Results The response rate of the curative effect of Imatinib in all patients was 87. 8%. The statistical analysis showed that there was no correlation between the curative effect of Imatinib and gender,age, tumor primary site(P>0. 05). The univariate analysis revealed that risk,dissection of primary tumor,metastatic le-sion are related to the curative effect of Imatinib ( P0.05)。单因素分析显示：危险度、转移灶手术情况、转移病灶与伊马替尼疗效有关(P<0.05)。多因素分析显示：转移灶手术情况、转移病灶是伊马替尼疗效的独立影响因素。逻辑回归分析显示：肝脏与多脏器转移，腹盆腔与多脏器转移的伊马替尼疗效差异有统计学意义(P<0.05)。结论危险度、转移灶手术情况、转移病灶是GIST伊马替尼疗效的影响因素，其中转移灶手术情况、转移病灶是伊马替尼疗效的独立影响因素；腹盆腔转移、肝脏转移、多脏器转移的伊马替尼疗效依次降低。