肌腱蛋白C在直肠癌及胃癌组织中的表达及临床意义

摘要

目的 研究肌腱蛋白C(TN-C)在直肠癌及胃癌组织中的表达及其临床意义.方法 采用免疫组织化学技术,分别对34例直肠癌及29例胃癌组织标本进行处理,分析TN-C在直肠癌及胃癌不同分化程度及临床分期中的表达强度.结果 34例直肠癌标本及29例胃癌标本均呈阳性表达;随着病理学分级的增高TN-C的表达逐渐增强,高分化与中分化、中分化与低分化癌变组织中TN-C表达相比,差异有统计学意义(P＜0.05);随着临床分期的增加,TN-C的表达也逐渐增强,Ⅰ～Ⅱ期直肠癌和胃癌患者组织TN-C表达与Ⅲ～Ⅳ期患者相比较,差异有统计学意义(P＜0.05).结论 在直肠癌及胃癌组织中均有TN-C的表达,且表达量与肿瘤分化程度及临床分期相关.%Objective To study the expression and clinical significance of tenascin C (TN-C) in rectal cancer and gastric cancer.Methods Immunohistochemistry technique was used to exam the expression of TN-C in 34 cases of rectal cancer and 29 cases of gastric cancer tissue.The correlation between TN-C expression and clinicopathologic stage in rectal cancer and gastric cancer was analyzed.Results All 34 cases of rectal cancer tissues and 29 cases of gastric cancer expressed TN-C.The expression of TN-C gradually increased with the pathological grading.There was statistically significance (P ＜ 0.05) of TN-C expression in cancer tissues of high differentiation campared with moderate differentiation,and moderate differentiaton compared with low differentiation.The expression of TN-C in cancer tissues gradually enhanced with the clinical stage.There was statistically significance (P ＜ 0.05) of TN-C expression in Ⅰ ～ Ⅱ rectal cancer and gastric cancer compared with that in Ⅲ ～ Ⅳ rectal and gastric cancer.Conclusion The expression of tenascin C in rectal cancer and gastric cancer is correlated with tumor differentiation and clinical stage.