2型糖尿病心血管因素与勃起功能障碍的关系

摘要

目的 研究2型糖尿病男性患者中心血管危险因素与勃起功能障碍(ED)的关系.方法 选取160例男性2型糖尿病住院患者为研究对象,采用国际勃起功能指数-5(IIEF-5)问卷评估勃起功能.根据评分结果将患者分为观察组(86例2型糖尿病合并ED的男性患者)及对照组(74例2型糖尿病不合并ED的男性患者).比较两组患者的相关心血管临床指标,采用二项分类Logistic回归分析ED的影响因素.结果 观察组中高血压、糖尿病视网膜病变、糖尿病肾病、冠心病的比例较对照组高(P<0.05).观察组患者颈内动脉内膜中层厚度(IMT)、尿白蛋白/肌酐比值(尿A/C比值)高于对照组(P<0.05).二项分类Logistic回归分析显示,在2型糖尿病男性患者中,IMT、Log尿A/C比值与ED相关(P<0.05).结论 2型糖尿病合并ED的男性患者更可能患有心血管疾病.早期检测与管理ED发病情况有利于提高2型糖尿病男性患者生活质量以及帮助识别高心血管疾病风险的糖尿病患者.%Objective To investigate the relationship between cardiovascular risk factors and erectile dysfunction(ED) among male patients with type 2 diabetes mellitus systematically.Methods A consecutive series of 160 male patients with type 2 diabetes were enrolled for this research.Erectile function was assessed by a short version of the international index of erectile function-5(IIEF-5).According to the scores of IIEF-5, they were divided into observation group(86 type 2 diabetic male patients with ED) and control group(74 type 2 diabetic male patients without ED).The clinical data were compared between these two groups, and the potential factors for ED were assessed by binary Logistic regression analysis.Results Hypertension, diabetic retinopathy, diabetic nephropathy and coronary heart disease were more prevalent in observation group than control group(P<0.05).The systolic pressure, carotid internal artery intima media thickness(IMT) and urinary albumin to creatinine ratio(A/C) in observation group were significantly higher than those in control group.In the binary Logistic regression model, IMT and urinary A/C ratio were associated with ED in type 2 diabetic male patients.Conclusion Type 2 diabetic patients with ED are more likely to have cardiovascular disease.Early detection and management of ED may improve quality of life and help to identify diabetic patients with high risk of cardiovascular disease.