聚氨酯中心静脉导管表面接枝聚维酮碘及抗菌性能研究

摘要

利用紫外光接枝技术,在聚氨酯中心静脉导管表面接枝聚乙烯基吡咯烷酮(聚维酮,PVP),再与碘络合,得到表面接枝聚维酮碘(PVP-I)的改性聚氨酯中心静脉导管(PU-g-PVP-I).将这种表面改性的中心静脉导管加到同样体积的液体培养基中,分别接种大肠杆菌、金黄色葡萄球菌、白色葡萄球菌和蜡状芽孢杆菌四种菌体,恒温培养15 ～ 18 h后得到抗菌性能曲线；结果表明,PU-g-PVP-I具有持久、广谱、高效的抗菌作用.%Polyvinylpyrrolidone (PVP) was grafted onto the surface of polyurethane central venous catheter with the UV grafting technology, and then the grafted PVP was complexed with iodine (I2 ) in ethanol to yield povidone iodine. In order to investigate the anti-bacterial property, the surface-modified catheter was put into the nutrient broth with the same volume in which Escherichia coli, Staphylococcus aureus, Staphylococcus albus, and Bacillus cereus were inoculated, respectively. The results show that the surface-modified central venous catheter has the anti-bacterial effect of long-lasting, broad-spectrum and high-efficiency.