无种子法纳米金棒的制备及其对肿瘤细胞光热治疗效应研究

摘要

采用简便快捷的无种子法一步完成了纳米金棒的制备。通过改变实验条件可以调控纳米金棒的吸收峰从可见到近红外转移。将巯基聚乙二醇(PEG-SH)置换金棒表面的十六烷基三甲基溴化铵（CTAB）分子，大大提高了金棒的生物相容性。制备的纳米金棒在近红外(NIR)光照射下对肿瘤细胞有很好的杀伤效果。研究结果为纳米金棒用于抗肿瘤治疗提供了实验基础。%We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol (PEG-SH) was then used to substitute cetyltrimethyl ammonium bromide (CTAB) to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cellgrowth was observed with the modified gold nanorods under near-infrared (NIR) light irradiation. Our results wil be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy.