副溶血弧菌的Ⅲ型分泌系统

摘要

Vibrio parahaemolyticus is a halophilic gram-negative bacterium that causes food borne acute gastroenteritis in humanbeing or certain diseases in aquatic species.In addition to thermostable direct hemolysin (tdh) and tdh-related hemolysin(trh),two sets of typeⅢsecretion systems(T3SS)were recently found to be associated closely with virulence.T3SS1 locatedon chromosome 1 is involved in cytotoxicity to host cells and orchestrates a multifaceted host cell infection by induction ofautophagy,cell rounding,and eventual cell lysis.T3SS2 in chromosome 2 is enterotoxic.In this we address the composition ofthe two T3SS.their functions and regulation in Vibrio parahaemolyticus.%副溶血弧菌是一种嗜盐性革兰氏阴性短杆菌,主要引起食物中毒性肠胃炎,还可引起水生动物疾病.除了耐热直接溶血毒素和耐热直接溶血相关毒素外,近年发现的副溶血弧菌两套Ⅲ型分泌系统也与该菌的致病性密切相关.Ⅲ型分泌系统1位于染色体l上,主要贡献对宿主细胞的细胞毒性,介导宿主细胞的自体吞噬作用,最后导致细胞死亡.Ⅲ型分泌系统2位于位于染色体2的毒力岛上,具有肠毒性.本文扼要介绍副溶血弧菌Ⅲ型分泌系统的组成、功能及相关转录调控机制.