蛋白质的甲基化研究进展

摘要

蛋白质翻译后修饰是调控蛋白质生物学功能的重要步骤之一.甲基化修饰作为蛋白质翻译后修饰的一种重要形式,参与了真核生物和原核生物的多种细胞进程.本文综述了目前蛋白质甲基化的研究进展,包括真核生物、原核生物,组蛋白和非组蛋白,以及多种氨基酸位点的甲基化修饰.这些发现丰富了人们对蛋白质甲基化修饰的认识,对深入了解蛋白质翻译后修饰的功能具有重要意义.%Protein post-translational modifications,as an important step in protein maturation,participate in the regulation of diverse protein biological functions.Methylation is one of the modifications and plays multiple roles in cellular processes,ranging from eukaryotes to prokaryotes.Protein methylation occurs on various amino acid residues,such as lysine,arginine,glutamine and others.This review summarized the progress in protein methylation,including both eukaryote and prokaryote,as well as histone and non-histone proteins.