武汉地区汉族人血管紧张素原基因变异与原发性高血压的关系探讨

摘要

利用对靶基因的PCR扩增片段进行酶切的方法对武汉地区汉族人血管紧张素原突变体(M235T与T174M)与原发性高血压发生的关系进行了分析。发现正常人和原发性高血压患者两组间M235T基因型频率分别为7％和14％(P>0．1)，T174M基因型频率分别为31％和51％(P>0．05)。初步结果表明，被检测者中血管紧张素原基因突变率在原发性高血压患者和正常人两组间没有显著性差异。%By polymerase chain reaction followed by restriction analysis the relationship between the polymorphism of the angiotensinogen (M235T and T174M) and essential hypertension was studied in the Han people of Wuhan area. It was found that the frequency of M235T and T174M was was 7 % and 31% in the healthy people and 14 % and 51 % in the patients with essential hypertension respectively. There were not significant differences in the mutation frequency of angiotensiongen between them.