c-Met与HER-2、HIF-1α在胃癌中的表达及临床意义

摘要

目的 研究c-Met 、人类表皮生长因子(HER-2)及低氧诱导因子(HIF-1α)在胃癌组织中的表达及与临床病理学特征的关系.方法 采用免疫组织化学法检测78例胃癌组织和41例癌旁正常胃组织中c-Met 、HER-2及 HIF-1α的表达,并分析胃癌中c-Met 、HER-2及 HIF-1α的表达与临床病理特征的关系.结果 c-Met 、HER-2以及 HIF-1α在胃癌组织中的阳性表达率显著高于癌旁正常组织,差异具有统计学意义(均 P＜0.05) .其中,HIF-1α蛋白的表达分别与胃癌组织的分化程度及临床分期、淋巴结转移相关(均 P＜0.05);c-Met的表达与胃癌分化程度及淋巴结转移相关(均 P＜0.05);HER-2的表达则与胃癌分化程度及临床分期相关(均 P＜0.05). HIF-1α的表达与 HER-2 、c-Met的表达呈正相关(均 P＜0.05);HER-2与c-Met的表达无相关性(P＞0.05).结论 c-Met与HER-2 、HIF-1α均与胃癌的侵袭转移密切相关,有望成为胃癌靶向治疗及临床监测的重要生物学指标.%Objective To study the relationship of the expression of c-Met ,human epidermal growth factor(HER-2)and hypoxia-inducible factor(HIF-1α)with the clinicopathological features of gastric carcinoma.Methods The expression of c-Met , HER-2 and HIF-1α in 78 cases of gastric carcinoma and 41 cases of normal gastric tissues was detected by immunohistochemical method. The relationship between the expression of c-Met ,HER-2 and HIF-1α and clinicopathological factors in gastric carcino-ma was analyzed.Results The positive rate of c-Met ,HER-2 and HIF-1α was significantly higher in gastric cancer than in adja-cent tissues(P＜0.05). The expression of HIF-1α was significantly correlated with the degree of differentiation ,clinical stage and lymph node metastasis in gastric carcinoma(P＜0.05).The expression of c-Met was significantly correlated with the degree of differentiation and lymph node metastasis(P＜0.05) ,while HER-2 was significantly correlated with the degree of differentia-tion and clinical stage in gastric carcinoma(P＜0.05).The expression of HER-2 and c-Met was positively correlated with the expression of HIF-1α(P＜0.05).There was no correlation between the expression of HER-2 and c-Met(P＞0.05).Conclusion c-Met and HER-2 and HIF-1α can be used as biological indicators of invasion and metastasis of gastric cancer ,providing a theoretical basis for the targeted treatment of gastric cancer ,and can be used as a basis for clinical monitoring indicators.