湖南汉族人群MICB等位基因多态性与白血病的相关性研究

摘要

Objective: To study on the polymorphism of MICB and its correlation with leukemia in Hunan Han population. Methods:PCR-SSP and PCR-SBT were used to analyze the gene polymorphism of MICB. Results; 13 allelic genes were found in patients of leukemia, and the frequency of MICB * 005 :02/010 was significantly lower than that of control group ( OR =0.416, P ＜ 0. 05 ) . There was no significant difference of MICB gene frequency between different types of leukemia. Conclusions:MICB * 005 ;02/010 allelic gene polymorphisms may be associated with leukemia protection.%目的:研究湖南汉族人群MICB等位基因的多态性与白血病的相关性.方法:MICB等位基因分型用PCR-SSP和PCR-SBT的方法.结果:白血病患者中有13种MICB等位基因被检测出,其中MICB * 005:02/010基因频率较对照组显著偏低(OR =0.416,P＜0.05).不同类别白血病之间MICB等位基因多态性没有显著差异.结论:MICB * 005:02/010等位基因可能与白血病的保护相关.