奥氮平联合逍遥丸治疗女性神经性厌食症对照研究

摘要

目的:观察奥氮平联合逍遥丸治疗神经性厌食症的疗效.方法:将46例神经性厌食症住院患者随机分为研究组(奥氮平联合逍遥丸)和对照组(单用奥氮平),每组23例,总疗程12周,疗程结束后随访6月.分别于治疗前及治疗后第2、6、12周及治疗结束后6月记录体重、月经恢复时间评定疗效,同时采用治疗副反应量表(Treatment Emergent Symptom Scale,TESS)评定不良反应.结果:研究组治疗2周体重较治疗前已有显著性增加(P＜0.05) ;治疗6周时两组体重增加有显著性差异(P＜0.05).研究组的患者平均月经恢复时间较对照组短,差异具有统计学意义(P＜0.05).研究组的不良反应发生率较对照组低,差异具有统计学意义(P＜0.05),TESS评分在治疗2周、6周两组间比较有显著性差异(P ＜0.01,P＜0.05).结论:奥氮平合并逍遥丸比单独使用奥氮平起效快,并且药物不良反小.%Objective: To study the effects of Olanzapine combined with Xiaoyao pill in anorexia nervosa . Methods: 46 inpatients were randomly divided into the treatment (Olanzapine combined with Xiaoyao pill) group (n =23) and control ( Olanzapine only) group ( n = 23). Patients of the treatment and control groups were given Olanzapine combined with Xiaoyao pill and Olanzapine only respectively. The clinical efficacy was evaluated with weight gain, the time of menses resumption and the safety of drugs was evaluated by using TESS at 1st,2nd,6th, 12th weekend and 6 months after treatment termination. Results: There was a significant weight gain in the treatment group at 2nd weekend,but not in the control group (P < 0. 05) , and the difference of weight gain at 6th weekend between the two groups was significant (P < 0. 05). The time of menses resumption in the treatment group was significantly earlier than that in the control group (P < 0. 05). The incidence of adverse reactions was significantly lower in the treatment group than that in the control group (P < 0. 05) , and the TESS scores of the treatment group both at 2nd and 6th weekend were significantly lower than those of the control group (P <0. 01, P <0. 05) , Conclusion; Olanzapine combined with Xiaoyao pill was effective and rapid onset in the treatment of anorexia nervosa with a low incidence of adverse reactions.